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DOI: 10.5593/SGEM2016/HB63/S08.051

UV RADIATIONS INFLUENCE ON THE TOTAL ANTIOXIDANT CAPACITY OF ARTIFICIAL TEARS (OCULAR LUBRICANT)

S. Jurja, T. Negreanu-Pirjol, B.S. Negreanu-Pirjol , F.N. Roncea
Friday 11 November 2016

References: 16th International Multidisciplinary Scientific GeoConference SGEM 2016, SGEM Vienna GREEN Extended Scientific Sessions, www.sgemviennagreen.org, SGEM2016 Conference Proceedings, ISBN 978-619-7105-79-7 / ISSN 1314-2704, 2 - 5 November, 2016, Book 6 Vol. 3, 395-400pp, DOI: 10.5593/SGEM2016/HB63/S08.051

ABSTRACT
The dry eye syndrome has become during the last decades more and more important, motivating a continuously expanding artificial tears research and production. In its multifactorial etiology, the essential role of environmental factors has been recognized. Under the circumstances of the ozone layer reduction, followed by an increased general irradiation, all antioxidative agents and mechanisms gained the highest importance for the wellness of living organisms, as a major defense weapon. Ophthalmic pharmaceutical products may also suffer influences caused by this irradiation growth, with potential influence on the effectiveness of these products. Considering this risk, we have determined the total antioxidant capacity of some ophthalmic pharmaceutical products referring to the type of artificial tears (ocular lubricant), using photochemiluminescence method, antioxidant capacity of lipid soluble substances (ACL) procedure, with Photochem apparatus, Analytik Jena AG, Germany. Also, we irradiated the artificial tears sample, in well plate for 2 minutes each, with UVC radiations source, at a distance of 2 cm between UV lamp and sample, twice repeated the procedure and the total antioxidant capacity evaluation. The results obtained might improve the efficiency of artificial tears (ocular lubricant) drops by revealing the different reactivity of these products under the sun influence, thus providing new criteria for the therapy selection. More stable products, whose total antioxidative activity remains more constant after UV irradiation, would represent the best choice during sunny seasons and for outdoor working people.

Keywords: artificial tears, UV radiations, total antioxidant capacity

PAPER DOI: 10.5593/SGEM2016/HB63/S08.051, UV RADIATIONS INFLUENCE ON THE TOTAL ANTIOXIDANT CAPACITY OF ARTIFICIAL TEARS (OCULAR LUBRICANT)

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