DBPapers
DOI: 10.5593/SGEM2014/B61/S25.067

SEMISOLID PHARMACEUTICAL PREPARATIONS BASED ON METALLIC COMPLEX COMPOUNDS OF CHLORHEXIDINE SALTS WITH ANTIMICROBIAL ACTIVITY

Negreanu–Pirjol T., Negreanu-Pirjol B.S., Roncea F., Sanda J., Sirbu R., Lepadatu A.C., Miresan H.
Wednesday 1 October 2014 by Libadmin2014

References: 14th International Multidisciplinary Scientific GeoConference SGEM 2014, www.sgem.org, SGEM2014 Conference Proceedings, ISBN 978-619-7105-20-9 / ISSN 1314-2704, June 19-25, 2014, Book 6, Vol. 1, 487-494 pp

ABSTRACT
The paper relates to pharmaceutical preparations type cream based on chlorhexidine metallic complex compounds and a process for their preparation. Pharmaceutical topical preparations for external use type creams described in the paper are destined to human health and veterinary medicine domain, regarding their disinfectant and antifungal action and can be used to teguments treat as dermatological germostop. For this reason we prepared several semisolid preparations (creams) based on synthesized metallic (CuII, AgI) complex compounds of chlorhexidine salts in oinment base type emulsion oil/water with lipophylic excipients. The antioxidant activity of these creams comparative to copper (II) and silver (I) complex compounds of chlorhexidine salts was determined by chemiluminescence method, based on the multiple acceleration of a natural reaction leading to the generation of a superoxide anion radical. The antioxidant capacity was quantified by comparison with standard luminol, using a Turner Design TD 20/20 SUA apparatus, at λ 420 nm wavelength. The comparative antimicrobial activity of semisolid pharmaceutical preparations and synthesized metallic (CuII, AgI) complex compounds of chlorhexidine salts by diffusion method on different bacterial and fungal strains (Staphylococcus aureus, Escherichia coli, Candida albicans) was evaluated. From the obtained results we noticed that comparative to the metallic complex compounds of chlorhexidine salts, the pharmaceutical preparations as cream type based on CuII and AgI complex of chlorhexidine (molar ratio 1:1:1) had an increased antioxidant capacity (88-94%) correlated with a higher antimicrobial activity.

Keywords: cream, chlorhexidine salts, metallic complex compounds, biological activity