DBPapers
DOI: 10.5593/sgem2012/s20.v5063

HEALTH AND ENVIRONMENTAL RISKS OF CYTOSTATICS PLATINUM GROUP RESIDUES

M. ZIMOVA, Z. WITTLINGEROVA, A. CIDLINOVA, A. PETRUZELKOVA, L. MATEJU, J. SPLICHALOVA, K. WRANOVA
Wednesday 1 August 2012 by Libadmin2012

References: 12th International Multidisciplinary Scientific GeoConference, www.sgem.org, SGEM2012 Conference Proceedings/ ISSN 1314-2704, June 17-23, 2012, Vol. 5, 471 - 478 pp

ABSTRACT

Interest in waste drugs in relation to their negative impact on the environment is
increasing during last years. Reason for that situation is high production and
consumption of drugs in the world and ineffective treatment of sewage containing
drugs.
Broad range of pharmaceuticals can be detected in aquatic environment now. Hospitals
use a great variety of substances for medical purposes, as diagnostics as well as for
therapy, care and research. Various groups of pharmaceuticals like analgesics,
antibiotics, lipid lowering agents, psychotropic drugs, cytostatic agents, contrast media,
as well as disinfectants can be detected in wastewater from hospitals and to some extent
even in surface and ground water.
The main route of human pharmaceuticals to the environment is through faeces to
sewage. Drugs are not easily degraded during wastewater treatment. They may
subsequently cause contamination of the environment including the food chain, when
sewage sludge is used as fertilizer of agricultural land.
Due to growing consumption of cytostatics containing heavy metals the threat of heavy
metals to environment is increasing. Removal of cytostatics from wastewaters is not
efficient as well as natural attenuation processes in environmental matrices. The project
“Research of technologies and methods of removing heavy metals from the Platinum
group of biological waste and their recycling options” addresses this issue. The project
proposes a solution for minimization of content of Platinum drugs and their metabolites
in environmental components after application of these drugs. The project proposes
further a detailed study of Platinum drugs in environment.
Obtained results show the contamination of working environment in hospitals.
Contamination was found in 88% of samples. Analysis was performed by ICP - MS
(plasma mass spectrometry), which allowed detection of 0.50 ng/l of Platinum
(5 pg/survey sample).
12th International Multidisciplinary Scientific GeoConference SGEM 2012
472
It was also demonstrated for waste water, where Pt levels ranged from 0.5 to 1.0 μm/l.
Sewage sludge contains 0.1 mg/kg.
New standards or amendments will be drafted aimed to reduction of health and
ecological risk with respect to potential mutagenicity and carcinogenicity of Platinum
compounds in biological wastes.

Keywords: cytostatics, platinum, risk, biological waste, environment