DBPapers

RESEARCH CONCERNING PHARMACOLOGICAL PROPERTIES OF SOME NEW XANTHINE COMPOUNDS

AUTHOR/S: L. PROFIRE
Sunday 1 August 2010 by Libadmin2008

8th International Scientific Conference - SGEM2008, www.sgem.org, SGEM2008 Conference Proceedings/ ISBN: 954-918181-2, June 16-20, 2008, Vol. 2, 723-730 pp

ABSTRACT

The new 7-[2-hydroxi-3-(4-acethyl-amino)-phenoxy-propyl]-8-R-1,3-dimethyl-xanthine
derivatives have been synthesized in order to increase the pharmacological properties of
theophylline. A QSAR study on pharmacological properties of some new xanthine
compounds have been realized to establish the most favorable structural modifications
for increase the action selectivity on cardiovascular system. Favorable influence of the
β-blocking sequence in 7 position of the xanthine ring has been established.

Keywords: xanthine, theophylline, cardiovascular system